FAQs about Plaque Psoriasis and Otezla® (apremilast)

Indications

Approved Uses Otezla^® (apremilast) is a prescription medicine used for the treatment of:

Adult patients with plaque psoriasis for whom phototherapy or systemic therapy is appropriate. Read more >

Approved Uses Otezla^® (apremilast) is a prescription medicine used for the treatment of:

Adult patients with plaque psoriasis for whom phototherapy or systemic therapy is appropriate.
Pediatric patients 6 years of age and older and weighing at least 20 kg with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy.
Adult patients with active psoriatic arthritis.
Adult patients with oral ulcers associated with Behçet’s Disease. Read less >

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Frequently asked questions

about Otezla.

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Whether you’re already taking Otezla or just want to learn more, it’s normal to have some questions about treatment. Take a look at some of the most commonly asked questions about Otezla.

What is Otezla?

What is Otezla^® (apremilast)?

Otezla is a prescription pill used to treat adults with plaque psoriasis or psoriatic arthritis. It is also approved for the treatment of oral ulcers associated with a rare condition called Behçet’s Disease.
Why would I take a pill instead of using a cream or ointment for plaque psoriasis?

Even though plaque psoriasis shows up on your skin, it’s actually caused by inflammation inside your body. Taking a pill like Otezla means you’re treating psoriasis where it starts. Talk to your doctor to make sure Otezla is the right treatment option for you.
Is Otezla a biologic?

No, Otezla is not a biologic. It is a phosphodiesterase 4 (PDE4) inhibitor. This means it reduces the activity of an enzyme called PDE4 inside the cells—which is then thought to reduce inflammation and plaque psoriasis symptoms. Learn more about how Otezla works.

Taking Otezla

How do I take Otezla?

When you start Otezla, you will slowly increase your dose over the first 5 days of treatment until you reach the recommended dose. This is known as a titration. People with severe kidney disease will follow a different schedule.

Titration is meant to help reduce the stomach and digestive side effects (nausea and diarrhea) that can happen when starting Otezla.

After your first 5 days, you will take Otezla twice daily—one pill in the morning and one at night. Be sure to take Otezla as directed by your doctor. Learn more by clicking here.
What are the side effects of Otezla?

The most common side effects of Otezla include diarrhea, nausea, upper respiratory tract infection, tension headache, and headache. These are not all the possible side effects of Otezla. Ask your doctor about other potential side effects.

Tell your doctor about any side effect that bothers you or does not go away. Learn more about the side effects of Otezla.
Are there certain medications I already take that could make Otezla less effective?

Yes, so it’s important to discuss all the medications you’re currently taking with your doctor. It may help to compile a list, and bring it to your appointment. You can also ask a pharmacist if you should not take some medications with Otezla.
How many people have taken Otezla?

Otezla has been studied in multiple clinical trials and has been approved by the FDA to treat both plaque psoriasis and psoriatic arthritis. Over 1 million people have been treated with Otezla globally,* and for over 10 years, doctors have been prescribing it.

^*Estimates of patients treated reflect global data since launch (Apr 2014-Sept 2023; US=57% of data). Calculations based on observed drug utilization parameters and number of units distributed. Utilization patterns change over time to best represent current markets.
I see Otezla treats psoriatic arthritis, so why would I take it for a skin condition like plaque psoriasis?

Otezla has been studied and approved to treat both plaque psoriasis and psoriatic arthritis. Both of these conditions are actually thought to be caused by an overactive immune system and are closely linked. In fact, up to 40% of people with psoriasis develop psoriatic arthritis.
Has Otezla been studied in pregnant women or in women who are breastfeeding?

Otezla has not been studied in pregnant women or women who are breastfeeding. Tell your doctor if you are pregnant, planning to become pregnant, or planning to breastfeed.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-332-1088.

How Otezla works

How does Otezla work?
The exact way in which Otezla works is not completely understood. Research has shown that Otezla blocks the activity of an enzyme found inside cells called phosphodiesterase 4 (PDE4). PDE4 is believed to contribute to the inflammation that comes with plaque psoriasis. By blocking PDE4, Otezla is thought to help reduce inflammation inside the body and lessen psoriasis symptoms. Learn more details about how Otezla works, or watch the video below.

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Otezla results

When can I expect to see results with Otezla?

Everyone’s experience is different, but after just 4 months, Otezla was proven to help some people achieve clearer skin. See how Otezla could help with the symptoms of plaque psoriasis.

Use this guide to discuss your results with your doctor.
Why do I need to take Otezla if my symptoms have improved?

Even though you may be feeling better, plaque psoriasis doesn’t go away. Otezla should be taken as prescribed, at the same times every day. Talk to your doctor if you experience any side effects.

Getting Otezla

How will I receive my Otezla prescription?

Your Otezla prescription will be delivered to you each month by a specialty pharmacy. Not sure what that means? Specialty pharmacies operate a lot like retail pharmacies, but they provide additional services and deliver your medication right to your door. Your specialty pharmacy will coordinate the delivery of your Otezla prescription and offer support, including access to pharmacists, refill reminders when you’re running low on your medication, and more.

Download this helpful Patient Roadmap or visit the Getting Your Prescription page for more details.
Is Otezla covered by my insurance?

Learn more about the ways Amgen^® SupportPlus can help you access your prescribed medication. Please call 1-844-4OTEZLA (1-844-468-3952). Someone is available 8 AM – 8 PM ET, Monday – Friday.
Find out more about Amgen SupportPlus.
Where can I find help paying for Otezla?

We know every patient has unique needs. And we’re here to provide financial support information and resources, regardless of your current financial situation or type of insurance you have.

Commercial Insurance (self-purchased or through an employer) If you are commercially insured, you can get Otezla for $0 per month by enrolling in the $0 Co-Pay* Program.

*Eligibility criteria and program maximums apply. Please see the full Terms and Conditions.

Medicare/Medicaid
Amgen SupportPlus Representatives can help you understand your current Medicare insurance plan and anticipated out-of-pocket costs for Otezla. If you want to switch Medicare plans, we can help identify other local options. We may also be able to refer you, if eligible, for Medicare Extra Help (Low Income Subsidy) or put you in touch with independent nonprofit foundations.^†

^†Eligibility for resources provided by independent nonprofit patient assistance programs is based on the nonprofit’s criteria. Amgen has no control over these programs and provides information as a courtesy only.

Please contact Amgen SupportPlus at 1-844-4OTEZLA (1-844-468-3952). Our team is here and ready to help Monday-Friday, 8 AM-8 PM ET.

I do not have insurance
If you are eligible, Amgen SupportPlus Representatives can provide information about independent nonprofit foundations that may be able to help.* Click here to get started by enrolling in Amgen SupportPlus or by calling 1-844-4OTEZLA (1-844-468-3952).
What is Co-Pay and the $0 Co-Pay* Program?

A co-pay (or co-payment) is a flat fee that is paid each time a patient goes to a doctor or fills a prescription. The $0 Co-Pay Program helps reduce that fee.

Patients with commercial insurance (self-purchased or through an employer) usually pay what is called the “out-of-pocket” cost for Otezla. This is the amount they owe after their insurance coverage has kicked in and any co-pays or deductibles have been applied.

Whether you were just prescribed Otezla or have been on Otezla, you can enroll in the $0 Co-Pay Program today. Once you have enrolled, you’ll receive a digital co-pay card via email. Share the member ID number on your card with your specialty pharmacy to begin lowering your out-of-pocket costs. Eligible, commercially insured patients may pay as little as $0 per month for Otezla.

The pharmacy can apply the $0 Co-Pay Card benefit (automatically) each month up to the annual maximum benefit of the co-pay program

The $0 Co-Pay Program is not for underinsured, Medicare, or Medicaid patients. If this is you, our team of Amgen SupportPlus Representatives can assist you with any questions you may have about your plan.

*Eligibility criteria and program maximums apply. Please see the full Terms and Conditions.
How do I get Co-Pay?

Signing up is simple, just fill out the form at Otezla.com/enroll, and if you’re eligible, you’ll automatically be enrolled. Once you have enrolled, you’ll receive a digital co-pay card via email. Share the member ID number on your card with your specialty pharmacy to begin lowering your out-of-pocket costs.

If you prefer to enroll over the phone, you can call 1-844-4OTEZLA (1-844-468-3952) and speak to an AmgenSupportPlus Representative (available 8 AM – 8 PM ET, Monday – Friday).

The Otezla Co-Pay Card is available to eligible patients with commercial insurance (usually self-purchased or through an employer) regardless of income level.
How long does enrollment in the $0 Co-Pay Program last?

Re-enrollment in the program is required at regular intervals. You may continue in the program as long as you re-enroll as required by Amgen and continue to meet all of the program’s eligibility requirements during participation in the program.

If at any point a patient’s insurance changes, their enrollment in the program may be re-evaluated. They must continue to meet the program’s eligibility requirements to continue receiving benefits.

About plaque psoriasis
and psoriatic arthritis

What is plaque psoriasis?

Plaque psoriasis is an autoimmune disease that appears on the skin in the form of red/purplish, itchy plaques. Find out more about what causes plaque psoriasis.
What is scalp psoriasis?

The scalp is one of the areas that’s most commonly affected by plaque psoriasis and can be hard to treat. It’s not just your everyday dandruff—scalp psoriasis is a form of plaque psoriasis that appears as thick, crusted plaques which cover parts of your scalp. It can extend beyond the hairline to the forehead, around the ears, and the back of the neck. It can also be extremely itchy.
What is psoriatic arthritis?

Psoriatic arthritis is an autoimmune disease. The most common symptoms of psoriatic arthritis include joint swelling, tenderness, and pain.

Know the signs of psoriatic arthritis
I have plaque psoriasis. Will I develop psoriatic arthritis?

Up to 40% of people with psoriasis also develop psoriatic arthritis, which can cause pain, stiffness, and swelling in and around the joints. Otezla can also treat psoriatic arthritis. Talk to your doctor if you experience any joint symptoms.

WHAT IS PSORIATIC ARTHRITIS?
Where can I find more information about plaque psoriasis?

Here are some helpful websites for plaque psoriasis information and support:

Resources and support

Are there any resources to help me when I start treatment?

Your doctor is always your best resource for any questions you might have about treatment, but we can help you find more information about getting started with Otezla once prescribed. For more information or to enroll into the Amgen SupportPlus program at otezla.com/supportplus.
How can I hear from others about their decision to start Otezla?

You’ll find stories from people living with plaque psoriasis and currently taking Otezla on our Patient Stories page.
Can I talk to a dermatologist from home?

Today, you can have an appointment from the comfort of your home. If you already have a dermatologist, check with them to find out which virtual or telehealth options may be available to you.

If they’re not available, or you don’t have a dermatologist, there are many telehealth services to choose from, such as Dermatologist On Call.

Visit Dermatologist On Call

As with any appointment, it’s important to remember that speaking with a dermatologist through a telehealth platform does not guarantee a prescription of Otezla or any other medication.
Will my prescription shipments be delayed due to COVID-19?

Otezla is delivered by a specialty pharmacy. Currently, we don’t anticipate any interruption in Otezla shipments.
Is there a supply shortage of Otezla?

No, Amgen continues to provide an uninterrupted supply of medicines for patients around the world. We don’t anticipate a shortage of Otezla at this time.

If you have questions or concerns regarding your supply of Otezla, you should contact your specialty pharmacy or Amgen SupportPlus at 1-844-4OTEZLA (1-844-468-3952).

IMPORTANT SAFETY INFORMATION

You must not take Otezla if you are allergic to apremilast or to any of the ingredients in Otezla.

Otezla can cause allergic reactions, sometimes severe. Stop using Otezla and call your healthcare provider or seek emergency help right away if you develop any of the following symptoms of a serious allergic reaction: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat or arms.

Otezla can cause severe diarrhea, nausea, and vomiting, especially within the first few weeks of treatment. Use in elderly patients and the use of certain medications with Otezla appears to increase the risk of complications from having severe diarrhea, nausea, or vomiting. Tell your doctor if any of these conditions occur.

Otezla is associated with an increase in depression. In clinical studies, some patients reported depression, or suicidal behavior while taking Otezla. Some patients stopped taking Otezla due to depression. Before starting Otezla, tell your doctor if you have had feelings of depression, or suicidal thoughts or behavior. Be sure to tell your doctor if any of these symptoms or other mood changes develop or worsen during treatment with Otezla.

Some patients taking Otezla lost body weight. Your doctor should monitor your weight regularly. If unexplained or significant weight loss occurs, your doctor will decide if you should continue taking Otezla. For children 6 years of age or older, their doctor should monitor their growth (height and weight). If they are not growing or gaining weight as expected, their doctor will decide if they should continue taking Otezla.

Some medicines may make Otezla less effective and should not be taken with Otezla. Tell your doctor about all the medicines you take, including prescription and nonprescription medicines.

The most common side effects of Otezla include diarrhea, nausea, upper respiratory tract infection, tension headache, and headache. These are not all the possible side effects with Otezla. Ask your doctor about other potential side effects. Tell your doctor about any side effect that bothers you or does not go away.

Tell your doctor if you are pregnant, planning to become pregnant or planning to breastfeed.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-332-1088.

Please click here for the Full Prescribing Information for Otezla.

APPROVED USES

Otezla^® (apremilast) is a prescription medicine used for the treatment of:

Adult patients with plaque psoriasis for whom phototherapy or systemic therapy is appropriate.
Pediatric patients 6 years of age and older and weighing at least 20 kg with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy.
Adult patients with active psoriatic arthritis.
Adult patients with oral ulcers associated with Behçet’s Disease.

IMPORTANT SAFETY INFORMATION

You must not take Otezla if you are allergic to apremilast or to any of the ingredients in Otezla.

Frequently asked questions

about Otezla.

You are leaving the Otezla website

What is Otezla?

Taking Otezla

How Otezla works

Otezla results

Getting Otezla

About plaque psoriasis and psoriatic arthritis

Resources and support

IMPORTANT SAFETY INFORMATION

APPROVED USES

IMPORTANT SAFETY INFORMATION

About plaque psoriasis
and psoriatic arthritis